The challenges of the optimal timing of parathyroid surgery in MEN1 syndrome patients and the available surgical strategies that may be adopted are discussed. The holistic approach and endocrinological MDT expertise required are emphasised in a pleasant conversation. The MEN1 Mosaic patient support podcast can be heard here: https://podcasts.apple.com/gb/podcast/the-men1- mosaic/id1788950243?i=1000704656666